Man with the Screaming Brain is a story of greed, betrayal and revenge in the big, bad city. William Cole, wealthy industrialist, winds up with part of his brain replaced by that of Yegor, a Bulgarian street hustler. The two couldn't be more different, but they share one thing - both were killed by the same woman. Brought back to life by a mad scientist, William and Yegor form an unlikely partnership to track down their common nemesis.